FINDING RELIEF VIDEO TRANSCRIPT

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LINZESS logo with USES and SAFETY CONSIDERATIONS, along with the first 2 bullets of IRI

USES

LINZESS^® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults and functional constipation (FC) in children and adolescents 6 to 17 years of age. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 18 years of age.

SAFETY CONSIDERATIONS

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Please see Important Safety Information including Boxed Warning at the end of the video.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

AVO: We've brought together 3 people to talk about their experience with Irritable Bowel Syndrome with Constipation or IBS-C and Chronic Idiopathic Constipation or CIC.

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DEB | Prescribed LINZESS for IBS-C

JULIE | Prescribed LINZESS for CIC

KIRK | Prescribed LINZESS for CIC

AVO: From when they first started to feel symptoms to finding a treatment that worked for them—

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LINZESS Logo

Presents

AVO: —this is The Constipation Conversation. In this episode, Finding Relief, our panel is discussing the moment when they first got on LINZESS.

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The Constipation Conversation logo

FINDING RELIEF

EPISODE 4

KIRK: When I was first prescribed LINZESS, my doctor covered all the risks and let me know what to expect.

JULIE: I’ve been cycled through treatments for years, but I was eager to try something else

DEB: I was frustrated with my constipation coming back again and again. LINZESS helps me stay regular.

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CONSTIPATION and BELLY PAIN are symptoms of IBS-C

KIRK: Within a week I knew this was working for me. When I’m leaving the bathroom, I don’t feel like I still need to go.

DEB: For me, it took a little longer, but I kept with it, and my doctor was there with me every step of the way.

JULIE: I rely on my routine. I stick to taking LINZESS every day at the same time.

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LINZESS is a once-daily pill

KIRK: I got my routine down in about 7 to 10 days.

JULIE: Your body’s got to adjust to this new kick-start that you’re giving it.

DEB: Once you get it, it’s predictable. You know—you know what’s going to happen. You know how you’re going to feel.

JULIE: With LINZESS and some proper planning, I feel like I’m better able to manage my condition.

KIRK: The advice I can give to new patients: Ask questions, don’t be embarrassed, give it a try—at least give it an honest try.

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KIRK’S ADVICE

Ask questions and don’t be embarrassed

JULIE: There is no magic bullet.

DEB: You have to let your body, you know, start to get used to it and understand the new way that you’re going to feel.

KIRK: You got to do...a little bit of work.

JULIE: Take the treatment and work with it, and you know, improve as you go along.

AVO: That concludes The Constipation Conversation. Share this video series with friends and family so they can better understand the signs and symptoms of IBS-C and CIC.

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The Constipation Conversation logo

THANK YOU FOR WATCHING

USES

SAFETY CONSIDERATIONS

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects
LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).

Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

[Abbvie Logo] | [Ironwood Logo]

AbbVie Inc.
1 North Waukegan Road
North Chicago, Illinois 60064-6163

Ironwood^® and its three-leaf design are registered trademarks of Ironwood Pharmaceuticals, Inc. LINZESS^® and its design are registered trademarks of Ironwood Pharmaceuticals, Inc.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

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By clicking “Acknowledge and Continue” above, you acknowledge and agree that neither AbbVie nor Ironwood does, in any way, endorse or recommend UpScript, a telemedicine provider, the qualifications of any physician associated with UpScript, or the quality of medical care any of those physicians can provide. You also acknowledge and agree that neither AbbVie nor Ironwood makes any guarantees that using UpScript will result in your desired outcome. It is wholly and solely your responsibility to assess the qualifications of a potential physician. AbbVie and Ironwood recommend that you meet and discuss the benefits and risks of all potential treatments with the potential physician. ABBVIE, IRONWOOD, AND THEIR RESPECTIVE AFFILIATES HEREBY DISCLAIM ANY LIABILITY ARISING FROM YOUR USE AND/OR RELIANCE ON THE INFORMATION CONTAINED ON THE UPSCRIPT WEBSITE. If you agree to the above, click “Acknowledge and Continue” to proceed to the UpScript website. If you do not agree to the above, click “Cancel” to remain on LINZESS.com.

IMPORTANT RISK INFORMATION

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).

Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

IMPORTANT RISK INFORMATION

Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are: